Biological markers of injury-induced immunosuppression - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Minerva Anestesiologica Année : 2023

Biological markers of injury-induced immunosuppression

Résumé

Severe injuries, such as severe sepsis, burn, trauma and major surgery, lead to an overlapping development of pro- and anti-inflammatory responses. It is now well established that these injuries are associated with the secondary development of immune suppression, which results in significant morbidity and mortality. Recent data suggest that immunostimulatory drugs might prevent these complications. However, intensive care patients are heterogeneous, making patient stratification essential for a targeted treatment. In the present review, we discuss potential biomarkers of injury-induced immunoparalysis, mainly focusing on these that have been associated with poor outcome in various clinical settings. We namely present clinical data on monocyte human leukocyte antigen DR, lymphopenia, PD-1/PD-L1 and transcriptomic approach.
Fichier principal
Vignette du fichier
Rouget Minerva 2017.pdf (700.04 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04064730 , version 1 (11-04-2023)

Identifiants

Citer

Christelle Rouget, Thibaut Girardot, Julien Textoris, Guillaume Monneret, Thomas Rimmelé, et al.. Biological markers of injury-induced immunosuppression. Minerva Anestesiologica, 2023, 83 (3), ⟨10.23736/S0375-9393.16.11268-4⟩. ⟨hal-04064730⟩

Collections

HCL UNIV-LYON1 UDL
31 Consultations
75 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More