Biological markers of injury-induced immunosuppression
Résumé
Severe injuries, such as severe sepsis, burn, trauma and major surgery, lead to an overlapping development of pro- and
anti-inflammatory responses. It is now well established that these injuries are associated with the secondary development
of immune suppression, which results in significant morbidity and mortality. Recent data suggest that immunostimulatory
drugs might prevent these complications. However, intensive care patients are heterogeneous, making patient
stratification essential for a targeted treatment. In the present review, we discuss potential biomarkers of injury-induced
immunoparalysis, mainly focusing on these that have been associated with poor outcome in various clinical settings. We
namely present clinical data on monocyte human leukocyte antigen DR, lymphopenia, PD-1/PD-L1 and transcriptomic
approach.
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