One-Pot, Solvent-Free Access to Unsymmetrical Ureas by Palladium-Catalysed Reductive Alkylation Using Molecular Hydrogen - Archive ouverte HAL Access content directly
Journal Articles European Journal of Organic Chemistry Year : 2013

One-Pot, Solvent-Free Access to Unsymmetrical Ureas by Palladium-Catalysed Reductive Alkylation Using Molecular Hydrogen

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Abstract

Unsymmetrical N,N′-disubstituted ureas were prepared in 60–93 % isolated yield by palladium-catalysed reductive alkylation of monosubstituted ureas using aldehydes as alkylating agents and molecular hydrogen as a clean reductant. A one-pot, solvent-free sequence was also developed from the corresponding amines.
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hal-03249259 , version 1 (04-06-2021)

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Tharwat Mohy El Dine, Simon Chapron, Marie-Christine Duclos, Nicolas Duguet, Florence Popowycz, et al.. One-Pot, Solvent-Free Access to Unsymmetrical Ureas by Palladium-Catalysed Reductive Alkylation Using Molecular Hydrogen. European Journal of Organic Chemistry, 2013, 2013 (24), pp.5445-5454. ⟨10.1002/ejoc.201300642⟩. ⟨hal-03249259⟩
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