Objectives:-To describe the evolution of the SARS-CoV-2 salivary viral load of patients infected with Covid-19, performing 7 days of tri-daily mouthwashes with and without antivirals.-To compare the evolution of the SARS-CoV-2 nasal and salivary viral load according to the presence or absence of antivirals in the mouthwash. Trial design: This is a multi-center, randomised controlled trial (RCT) with two parallel arms (1:1 ratio). Participants: Inclusion criteria-Age: 18-85 years old-Clinical diagnosis of Covid-19 infection-Clinical signs have been present for less than 8 days-Virological confirmation-Understanding and acceptance of the trial-Written agreement to participate in the trial Exclusion criteria-Pregnancy, breastfeeding, inability to comply with protocol, lack of written agreement-Patients using mouthwash on a regular basis (more than once a week)-Patient at risk of infectious endocarditis-Patients unable to answer questions-Uncooperative patient The clinical trial is being conducted with the collaboration of three French hospital centers: Hospital Center Emile Roux (Le Puy en Velay, France), Clinic of the Protestant Infirmary (Lyon, France) and Intercommunal Hospital Center (Mont de Marsan, France).