Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla - Université Claude Bernard Lyon 1 Access content directly
Journal Articles Fitoterapia Year : 2009

Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla

Abstract

Bio-guided fractionation of the roots of Paris polyphylla (Trilliaceae), based on inhibition of P-glycoprotein-mediated daunorubicin efflux in K562/R7 cell line, led to isolation and identification of the three saponins 3-O-Rha(12)[Ara(14)]Glc-pennogenine, gracillin and polyphyllin D, and the two ecdysteroids 20-hydroxyecdysone and pinnatasterone. These compounds were tested for multidrug reversion on P-glycoprotein (ABCB1) with both drug-selected and transfected cell lines, and also on Breast Cancer Resistance Protein (BCRP/ABCG2). By contrast to a weak efficiency on BCRP, the three saponins displayed significant effects as inhibitors of P-glycoprotein-mediated drug efflux.

Dates and versions

hal-02545047 , version 1 (16-04-2020)

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van Thi Bao Nguyen, Nicole Darbour, Christine Bayet, A. Doreau, Imad Raad, et al.. Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla. Fitoterapia, 2009, 80 (1), pp.39-42. ⟨10.1016/j.fitote.2008.09.010⟩. ⟨hal-02545047⟩
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