Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue The Lancet Année : 2017

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Ting Shi (1) , David Mcallister (2) , Katherine O'Brien (3) , Eric Simoes (4) , Shabir Madhi (5) , Bradford Gessner (6) , Fernando Polack , Evelyn Balsells , Sozinho Acacio , Claudia Aguayo , Issifou Alassani (7) , Asad Ali (8) , Martin Antonio (9) , Shally Awasthi (10) , Juliet Awori (11) , Eduardo Azziz-Baumgartner (12) , Henry Baggett (13) , Vicky Baillie (5) , Angel Balmaseda (14) , Alfredo Barahona , Sudha Basnet (15) , Quique Bassat (16) , Wilma Basualdo , Godfrey Bigogo (11) , Louis Bont (17) , Robert Breiman (18) , W Abdullah Brooks (3) , Shobha Broor (19) , Nigel Bruce (20) , Dana Bruden , Philippe Buchy (4) , Stuart Campbell , Phyllis Carosone-Link (4) , Mandeep Chadha , James Chipeta , Monidarin Chou (21) , Wilfrido Clara (22) , Cheryl Cohen (5) , Elizabeth de Cuellar , Duc-Anh Dang (23) , Budragchaagiin Dash-Yandag , Maria Deloria-Knoll , Mukesh Dherani (20) , Tekchheng Eap (24) , Bernard Ebruke (9) , Marcela Echavarria , Carla Cecília de Freitas Lázaro Emediato , Rodrigo A Fasce (25) , Daniel Feikin (22) , Luzhao Feng (22) , Angel Gentile (26) , Aubree Gordon (27) , Doli Goswami (12) , Sophie Goyet (4) , Michelle Groome , Natasha Halasa (28) , Siddhivinayak Hirve (29) , Nusrat Homaira (12) , Stephen R C Howie (30) , Jorge Jara (31) , Imane Jroundi (16) , Cissy Kartasasmita , Najwa Khuri-Bulos (32) , Karen Kotloff , Anand Krishnan (19) , Romina Libster , Olga Lopez , Marilla Lucero (33) , Florencia Lucion (26) , Socorro Lupisan (33) , Debora Marcone , John Mccracken (31) , Mario Mejia , Jennifer Moisi (6) , Joel Montgomery (22) , David Moore , Cinta Moraleda (16) , Jocelyn Moyes (5) , Patrick Munywoki (11) , Kuswandewi Mutyara , Mark Nicol (34) , James Nokes (11) , Pagbajabyn Nymadawa , Maria da Costa Oliveira , Histoshi Oshitani (35) , Nitin Pandey (10) , Gláucia Paranhos-Baccalà (36) , Lia Phillips (37) , Valentina Sanchez Picot , Mustafizur Rahman (12) , Mala Rakoto-Andrianarivelo (38) , Zeba Rasmussen (39) , Barbara Rath , Annick Robinson , Candice Romero , Graciela Russomando (40) , Vahid Salimi (41) , Pongpun Sawatwong (13) , Nienke Scheltema (17) , Brunhilde Schweiger (42) , J Anthony G Scott , Phil Seidenberg (43) , Kunling Shen , Rosalyn Singleton (22) , Viviana Sotomayor , Tor Strand , Agustinus Sutanto , Maria Sylla , Milagritos Tapia , Somsak Thamthitiwat (13) , Elizabeth Thomas (39) , Rafal Tokarz (44) , Claudia Turner , Marietjie Venter (45) , Sunthareeya Waicharoen (13) , Jianwei Wang (46) , Wanitda Watthanaworawit , Lay-Myint Yoshida (47) , Hongjie Yu (22) , Heather Zar (34) , Harry Campbell (1) , Harish Nair (1)
1 Edin. - University of Edinburgh
2 University of Glasgow
3 Johns Hopkins Bloomberg School of Public Health [Baltimore]
4 University of Colorado Anschutz [Aurora]
5 WITS - University of the Witwatersrand [Johannesburg]
6 Agence de Médecine Préventive
7 Ministry of Health [Togo]
8 Aga Khan University
9 MRC - Medical Research Council Unit The Gambia
10 King George's Medical University
11 KEMRI - Kenya Medical Research Institute
12 ICDDR,B - International Centre for Diarrhoeal Disease Research, Bangladesh
13 Ministry of Public Health [Thailand]
14 MINSA - Ministry of Health [Nicaragua]
15 Centre for International Health [Bergen, Norway]
16 UB - Universitat de Barcelona
17 University Medical Center [Utrecht]
18 EGHI - Emory Global Health Institute [Atlanta]
19 All India Institute of Medical Sciences
20 University of Liverpool
21 UHS - University of Health Sciences [Phnom-Penh, Cambodia]
22 Centers for Disease Control and Prevention
23 NIHE - National Institute of Hygiene and Epidemiology [Hanoi, Vietnam]
24 National Pediatric Hospital
25 Public Health Institute of Chile
26 Austral University
27 University of Michigan [Ann Arbor]
28 Vanderbilt University [Nashville]
29 KEM Hospital Research Center
30 University of Auckland [Auckland]
31 Universidad del Valle de Guatemala
32 JU - The University of Jordan
33 Research Institute for Tropical Medicine
34 University of Cape Town
35 Tohoku University Graduate School of Medicine
36 LPE-Fondation Mérieux - Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory
37 Rollins School of Public Health
38 Centre d’Infectiologie Charles-Mérieux, Université d’Antananarivo - Madagascar
39 NCI-NIH - National Cancer Institute [Bethesda]
40 UNA - Universidad Nacional de Asunción [Paraguay] = National University of Asunción = Université nationale d'Asunción
41 TUMS - Tehran University of Medical Sciences
42 RKI - Robert Koch Institute [Berlin]
43 The University of New Mexico [Albuquerque]
44 Columbia Mailman School of Public Health
45 University of Pretoria [South Africa]
46 China Academy of Chinese Medical Sciences
47 Nagasaki University
Ting Shi
  • Fonction : Auteur
Fernando Polack
  • Fonction : Auteur
Evelyn Balsells
  • Fonction : Auteur
Sozinho Acacio
  • Fonction : Auteur
Claudia Aguayo
  • Fonction : Auteur
Asad Ali
  • Fonction : Auteur
Alfredo Barahona
  • Fonction : Auteur
Wilma Basualdo
  • Fonction : Auteur
Dana Bruden
  • Fonction : Auteur
Philippe Buchy
Stuart Campbell
  • Fonction : Auteur
Mandeep Chadha
  • Fonction : Auteur
James Chipeta
  • Fonction : Auteur
Elizabeth de Cuellar
  • Fonction : Auteur
Budragchaagiin Dash-Yandag
  • Fonction : Auteur
Maria Deloria-Knoll
  • Fonction : Auteur
Marcela Echavarria
  • Fonction : Auteur
Angel Gentile
  • Fonction : Auteur
Sophie Goyet
Michelle Groome
  • Fonction : Auteur
Jorge Jara
Cissy Kartasasmita
  • Fonction : Auteur
Karen Kotloff
  • Fonction : Auteur
Romina Libster
  • Fonction : Auteur
Olga Lopez
  • Fonction : Auteur
Debora Marcone
  • Fonction : Auteur
Mario Mejia
  • Fonction : Auteur
David Moore
  • Fonction : Auteur
Kuswandewi Mutyara
  • Fonction : Auteur
Pagbajabyn Nymadawa
  • Fonction : Auteur
Maria da Costa Oliveira
  • Fonction : Auteur
Valentina Sanchez Picot
  • Fonction : Auteur
Barbara Rath
  • Fonction : Auteur
  • PersonId : 766812
  • IdRef : 198085532
Annick Robinson
  • Fonction : Auteur
Candice Romero
  • Fonction : Auteur
J Anthony G Scott
  • Fonction : Auteur
Kunling Shen
  • Fonction : Auteur
Viviana Sotomayor
  • Fonction : Auteur
Tor Strand
  • Fonction : Auteur
Agustinus Sutanto
  • Fonction : Auteur
Maria Sylla
  • Fonction : Auteur
Milagritos Tapia
  • Fonction : Auteur
Elizabeth Thomas
  • Fonction : Auteur
  • PersonId : 980966
Claudia Turner
  • Fonction : Auteur
Wanitda Watthanaworawit
  • Fonction : Auteur
Hongjie Yu
  • Fonction : Auteur
  • PersonId : 955563
Heather Zar
  • Fonction : Auteur
  • PersonId : 903359
Harry Campbell
  • Fonction : Auteur
  • PersonId : 892355

Résumé

BACKGROUND: We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration, we aimed to estimate the global incidence, hospital admission rate, and mortality from RSV-ALRI episodes in young children in 2015. METHODS: We estimated the incidence and hospital admission rate of RSV-associated ALRI (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions from a systematic review of studies published between Jan 1, 1995, and Dec 31, 2016, and unpublished data from 76 high quality population-based studies. We estimated the RSV-ALRI incidence for 132 developing countries using a risk factor-based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by combining in-hospital case fatality ratios with hospital admission estimates from hospital-based (published and unpublished) studies. We also estimated overall RSV-ALRI mortality by identifying studies reporting monthly data for ALRI mortality in the community and RSV activity. FINDINGS: We estimated that globally in 2015, 33·1 million (uncertainty range [UR] 21·6-50·3) episodes of RSV-ALRI, resulted in about 3·2 million (2·7-3·8) hospital admissions, and 59 600 (48 000-74 500) in-hospital deaths in children younger than 5 years. In children younger than 6 months, 1·4 million (UR 1·2-1·7) hospital admissions, and 27 300 (UR 20 700-36 200) in-hospital deaths were due to RSV-ALRI. We also estimated that the overall RSV-ALRI mortality could be as high as 118 200 (UR 94 600-149 400). Incidence and mortality varied substantially from year to year in any given population. INTERPRETATION: Globally, RSV is a common cause of childhood ALRI and a major cause of hospital admissions in young children, resulting in a substantial burden on health-care services. About 45% of hospital admissions and in-hospital deaths due to RSV-ALRI occur in children younger than 6 months. An effective maternal RSV vaccine or monoclonal antibody could have a substantial effect on disease burden in this age group. FUNDING: The Bill & Melinda Gates Foundation.

Dates et versions

hal-01976733 , version 1 (10-01-2019)

Identifiants

Citer

Ting Shi, David Mcallister, Katherine O'Brien, Eric Simoes, Shabir Madhi, et al.. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. The Lancet, 2017, 390 (10098), pp.946-958. ⟨10.1016/S0140-6736(17)30938-8⟩. ⟨hal-01976733⟩
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