A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry - Université Claude Bernard Lyon 1 Access content directly
Journal Articles Journal of flow chemistry Year : 2012

A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry

Abstract

A methodology that may be applied to help in the choice of a continuous reactor is proposed. In this methodology, the chemistry is first described through the use of eight simple criteria (rate, thermicity, deactivation, solubility, conversion, selectivity, viscosity, and catalyst). Then, each reactor type is also analyzed from their capability to answer each of these criteria. A final score is presented using "spider diagrams." Lower surfaces indicate the best reactor choice. The methodology is exemplified with a model substrate nitrobenzene and a target pharmaceutical intermediate, N-methyl-4-nitrobenzenemethanesulphonamide, and for three different continuous reactors, i.e., stirred tank, fixed bed, and an advanced microstructured reactor. Comparison with the traditional batch reactor is also provided.
No file

Dates and versions

hal-01925285 , version 1 (16-11-2018)

Identifiers

Cite

Tuong van Le Doan, Petr Stavárek, Claude de Bellefon. A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry. Journal of flow chemistry, 2012, 2 (3), pp.77 - 82. ⟨10.1556/JFC-D-12-00014⟩. ⟨hal-01925285⟩
8 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More