In vivo evaluation of the potential neurotoxicity of aerosols released from mechanical stress of nano-TiO2 additived paints in mice chronically exposed by inhalation
Résumé
Engineered Nanomaterials (ENM) provide technical and specific benefits due to theirphysical-chemical properties at the nanometer scale. For instance, many ENM are used to improveproducts in the building industry. Nanoscaled titanium dioxide (TiO2) is one of the most used ENM inthis industry. Incorporated in different matrix, cement, glass, paints… TiO2 nanoparticles (NPs) providethe final product with anti-UV, air purification and self-cleaning properties, thanks to theirphotocatalytic activity. However, ageing processes of such products, as photocatalytic paints, during amechanical stress have been shown to release TiO2 NPs from this matrix associated with sanding dust.Thus, workers who sand painted walls could be exposed to TiO2 NPs through inhalation. As inhalationmay lead to a translocation of particulate matter to the brain via olfactory or trigeminal nerves, there isan urgent need for evaluating a potential neurotoxicity. In order to provide new knowledge on this topic,we developed a dedicated experimental set-up using a rodent model exposed via inhalation. The aerosolreleased from a mechanical stress of photocatalytic paints containing TiO2 NPs was characterized andcoupled to an exposition chamber containing group of mice free to move and chronically exposed(2 hours per day for 5 days a week during 8 weeks).
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