Trifluoromethoxylation of Arynes using 2,4‐Dinitro‐1‐(trifluoromethoxybenzene) as Trifluoromethoxide Anion Source - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2024

Trifluoromethoxylation of Arynes using 2,4‐Dinitro‐1‐(trifluoromethoxybenzene) as Trifluoromethoxide Anion Source

Résumé

The trifluoromethoxy moiety, an emerging fluorinated group, shows interesting properties for pharmaceutical and agrochemical applications. However, only few methods have been reported for the direct introduction of this group on molecules with high efficiency, safety and low cost. Indeed, most of direct trifluoromethoxylation reagents are either expensive, hazardous or require preliminary synthesis before their use. Here we describe the use of 2,4-dinitro-1-(trifluoromethoxy)benzene (DNTFB) as an easy-to-handle, safe, commercially available and cheap source of trifluoromethoxide anion for the trifluoromethoxylation of arynes.

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Chimie organique
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hal-04591124 , version 1 (28-05-2024)

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Lilian Wisson, Gilles Hanquet, Fabien Toulgoat, Thierry Billard, Armen Panossian, et al.. Trifluoromethoxylation of Arynes using 2,4‐Dinitro‐1‐(trifluoromethoxybenzene) as Trifluoromethoxide Anion Source. European Journal of Organic Chemistry, inPress, ⟨10.1002/ejoc.202400388⟩. ⟨hal-04591124⟩
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