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Article Dans Une Revue NeuroImage Année : 2021

Combining brain perturbation and neuroimaging in non-human primates

Jean-François Aubry
Vincent P. Ferrera
Sean Froudist-Walsh
Anna S. Mitchell
Hiroyuki Oya
Angela C. Roberts
Jordy Tasserie
  • Fonction : Auteur
Lynn Uhrig
Christopher I. Petkov

Résumé

Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination of brain perturbation methods and neural measurement techniques is inherently challenging, research in humans has predominantly focused on non-invasive, indirect brain perturbations, or neurological lesion studies. Non-human primates have been indispensable as a neurobiological system that is highly similar to humans while simultaneously being more experimentally tractable, allowing visualization of the functional and structural impact of systematic brain perturbation. This review considers the state of the art in non-human primate brain perturbation with a focus on approaches that can be combined with neuroimaging. We consider both non-reversible (lesions) and reversible or temporary perturbations such as electrical, pharmacological, optical, optogenetic, chemogenetic, pathway-selective, and ultrasound based interference methods. Method-specific considerations from the research and development community are offered to facilitate research in this field and support further innovations. We conclude by identifying novel avenues for further research and innovation and by highlighting the clinical translational potential of the methods.

Domaines

Neurosciences
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Dates et versions

hal-03288050 , version 1 (01-06-2022)

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Paternité

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Peter Christiaan Klink, Jean-François Aubry, Vincent P. Ferrera, Andrew S. Fox, Sean Froudist-Walsh, et al.. Combining brain perturbation and neuroimaging in non-human primates. NeuroImage, 2021, 235, ⟨10.1016/j.neuroimage.2021.118017⟩. ⟨hal-03288050⟩
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