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T*
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T*
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(\()Tj
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(p)Tj
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[(0.09\))-284.3(\(Table)-280.9(2\).)]TJ
/F3 1 Tf
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[(Iron)-331.7(Accumulation)-338.9(and)-331.9(Oxidative)-339(Stress)-330.1(Reduction)]TJ
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[(Under)-335.4(Deferiprone)-337.2(in)-331.6(Early)-333.4(ALS)-335.2(Patients)]TJ
/F4 1 Tf
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T*
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(i.e.)Tj
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[(,)-389.3(the)-390.5(cerebellum)-397.3(and)-390.4(the)-396.3(oc-)]TJ
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T*
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[(Conservative)-331.5(Iron)-338(Chelation)]TJ
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T*
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T*
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T*
[(as)-262.4(ha)19.7(s)-265.8(b)0(e)13.9(e)0(n)-256.8(o)0(b)20.8(s)0(e)14.1(r)0(v)20.9(e)0(d)-256.8(i)0(n)-261.5(P)0(a)19.8(r)0(k)15.1(i)0(n)20.7(s)0(o)21(n)0()20.9(s)-271.6(di)20.7(se)19.9(as)19.9(e)-273(\()0(2)20.9(\))0(.)]TJ
1.0137 -1.1174 TD
[(Deferiprone)-356.3(s)16.4(i)16.1(g)16.2(n)0(i)26.5()16.3(c)15(a)15(n)0(t)26.5(l)16(y)-335.2(i)0(n)26.5(c)15(r)16.2(e)15(a)15(s)0(e)25.6(d)-335.2(su)26.8(r)16.2(v)16.2(i)16.1(va)25.4(l)16(,)-337.5(a)15(s)-340.7(p)16.2(r)16.2(e)15(v)16.2(i)0(o)26.5(u)16.2(s)16.4(l)16(y)]TJ
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[(repo)-15.9(r)10.7(t).1(ed)-391.4(wit)-15.9(h)-375.3(o)-15.9(t)10.6(her)-391.3(i).2(ro)-15.9(n)-375.2(c)-15.9(h)9.5(e)-.9(lato)-15.9(r)10.7(s)-391.2(\(3,)-393.7(5\).)-388(T)-15.9(h)9.5(is)-391.2(was)-391.2(obs)-15.9(e)9.7(rved)]TJ
T*
-.0157 Tc
[(desp)-15.7(i)10.8(t).3(e)-444.2(t)-15.7(r)10.8(eatme)-15.7(n)9.7(t)-443.1(in)-15.7(i)10.8(t).4(iat)-15.7(i)10.6(on)-448.8(at)-443.1(th)-15.7(e)-433.8(s).7(ym)-15.7(p)9.7(t).3(omati)-15.7(c)-433.9(st)-15.7(a)9.6(g).5(e)-444.2(i)-15.7(n)-432.7(t).4(h)-15.7(e)]TJ
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[(pheno)-16.1(t)10.4(ypic)-16.1(a)8.2(lly)-460.7(a)-1.1(ggre)-16.1(s)9.5(s).3(iv)-16.1(e)-445.7(S).2(O)-16.1(D)8.8(1)]TJ
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-.0208 Tc
(G86R)Tj
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-.0158 Tc
[(mode)-15.8(l)9.5(.)-457(An)-460.4(inter)-15.8(a)9.7(ction)]TJ
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[(betwe)-15.8(e)8.5(n)-460.4(dose)-461.6(a)-.8(n)-15.8(d)-444.2(s)-15.8(e)9.8(x)-460.4(w)-.5(as)-460.2(obs)-15.8(e)9.8(rved)-15.8(;)-450.1(disea)-15.8(s)9.8(e)-461.6(s).6(ever)-15.8(i)10.7(t).3(y,)-462.7(iron)]TJ
T*
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[(in)-281.5(femal)-15.5(e)9.8(s).9(.)]TJ
1.0137 -1.1116 TD
0 Tc
[(Deferiprone)-448.5(had)-453.7(a)-445.8(good)-453.7(safety)-452.3(prole)-445.4(in)-451.6(patients,)-452.5(with)]TJ
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[(adverse)-287.4(events)-285.3(mostly)-284.4(relating)-288(to)-284.5(persistent)-289.8(ALS)-281.7(symptoms.)]TJ
ET
59.754 732.019 239.131 .51025 re
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59.754 715.124 .51024 17.405 re
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298.375 715.124 .51022 17.405 re
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59.754 704.126 .51024 10.998 re
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298.375 704.126 .51022 10.998 re
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59.754 693.184 .51024 10.942 re
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298.375 693.184 .51022 10.942 re
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59.754 682.242 .51024 10.942 re
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298.375 682.242 .51022 10.942 re
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59.754 671.244 .51024 10.998 re
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298.375 671.244 .51022 10.998 re
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59.754 660.302 .51024 10.942 re
f
298.375 660.302 .51022 10.942 re
f
59.754 649.36 .51024 10.942 re
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298.375 649.36 .51022 10.942 re
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59.754 638.362 .51024 10.998 re
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298.375 638.362 .51022 10.998 re
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298.375 594.538 .51022 10.942 re
f
59.754 572.655 239.131 .45355 re
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59.754 572.655 .51024 21.883 re
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298.375 572.655 .51022 21.883 re
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BT
/F3 1 Tf
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(Innovation)Tj
/F4 1 Tf
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[(The)-385.8(present)-384.3(work)-385.4(provides)-384.3(the)-384.7(rst)-384.3(clinical)-387.2(evidence)]TJ
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[(about)-404.2(the)-407.8(neuroprotective)-413.2(potential)-404.4(of)-405.3(a)-405.4(therapeutically)]TJ
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[(safe)-340.6(chelation)-347.9(treatment)-343.3(on)-342(early-stage)-345.1(amyotrophic)-344.2(lat-)]TJ
0 -1.1116 TD
[(eral)-450.3(sclerosis)-449.6(\(ALS\))-450.8(patients,)-452.5(which)-451.2(responded)-455.5(signi-)]TJ
T*
[(cantly)-619.7(to)-624.4(treatment)-619.8(in)-624.4(both)-620.8(brain)-623.1(iron)-620.8(deposits)-620.4(and)]TJ
0 -1.1174 TD
[(indicators)-462.8(of)-462.9(disease)-466(progression.)-465.7(The)-466.4(novel)-461.8(treatment)]TJ
0 -1.1116 TD
[(relied)-325.9(on)-330.5(oral)-328.2(administration)-330.4(of)-330.5(deferiprone)-332.4(that)-328.4(by)-324.7(che-)]TJ
T*
[(lation)-468.9(of)-474.5(labile)-470.1(iron)-471(it)-474.8(conferred)-474.1(on)-468.7(oxidation-st)-8.9(ressed)]TJ
0 -1.1174 TD
[(animals,)-585(improved)-581.5(motor)-582.8(functions,)-584.8(while)-583.8(essentially)]TJ
0 -1.1116 TD
[(sparing)-573.2(systemic)-576.7(iron.)-572.4(The)-570.1(paradigmatic)-578.2(modality)-576(of)]TJ
T*
[(chelation)-336.3(with)-339.6(deferiprone)-343.9(in)-336.4(ALS)-333.5(has)-338.3(prompted)-339.6(a)-336.3(mul-)]TJ
T*
[(ticenter)-283.4(study.)]TJ
/F3 1 Tf
8.9663 0 0 8.9663 59.7543 749.7069 Tm
[(DEFERIPRONE)-343.9(IN)-328.8(ALS)]TJ
53.0113 0 TD
(743)Tj
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