COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression - Archive ouverte HAL Access content directly
Journal Articles Journal of Clinical Medicine Year : 2020

COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression

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Florence Carrouel
Julian Fisher
  • Function : Author
  • PersonId : 1068235
Lucio Souza Gonçalves
  • Function : Author
Claude Dussart
  • Function : Author
  • PersonId : 1068000
Denis Bourgeois

Abstract

Considered to be a major portal of entry for infectious agents, the oral cavity is directly associated with the evolutionary process of SARS-CoV-2 in its inhalation of ambient particles in the air and in expectorations. Some new generations of mouth rinses currently on the market have ingredients that could contribute to lower the SARS-CoV-2 viral load, and thus facilitate the fight against oral transmission. If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain β-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. We urge national agencies and authorities to start clinical trials to evaluate the preventive effects of βCD-Citrox therapeutic oral biofilm rinses in reducing the viral load of the infection and possibly disease progression.
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Dates and versions

hal-02545367 , version 1 (17-04-2020)

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Florence Carrouel, Maria Conte, Julian Fisher, Lucio Souza Gonçalves, Claude Dussart, et al.. COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression. Journal of Clinical Medicine, 2020, 2020, ⟨10.3390/jcm9041126⟩. ⟨hal-02545367⟩
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