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Journal Articles Molecular and Cellular Endocrinology Year : 2017

MicroRNAs in pituitary tumors

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1
A. Wierinckx
  • Function : Author
M. Roche
  • Function : Author
J. Trouillas
  • Function : Author
G. Raverot
  • Function : Author
J. Lachuer
  • Function : Author

Abstract

Since the presence of microRNAs was first observed in normal pituitary, the majority of scientific publications addressing their role and the function of microRNAs in the pituitary have been based on pituitary tumor studies. In this review, we briefly describe the involvement of microRNAs in the synthesis of pituitary hormones and we present a comprehensive inventory of microRNA suppressors and inducers of pituitary tumors. Finally, we summarize the functional role of microRNAs in tumorigenesis, progression and aggressiveness of pituitary tumors, mechanisms contributing to the regulation (transcription factors, genomic modifications or epigenetic) or modulation (pharmacological treatment) of microRNAs in these tumors, and the interest of thoroughly studying the expression of miRNAs in body fluids.
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hal-02487203 , version 1 (21-02-2020)

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A. Wierinckx, M. Roche, Catherine Legras-Lachuer, J. Trouillas, G. Raverot, et al.. MicroRNAs in pituitary tumors. Molecular and Cellular Endocrinology, 2017, Small non-coding RNAs (and microRNAs) in endocrinology, 456 (C), pp.51-61. ⟨10.1016/j.mce.2017.01.021⟩. ⟨hal-02487203⟩
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