MicroRNAs in pituitary tumors - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Molecular and Cellular Endocrinology Année : 2017

MicroRNAs in pituitary tumors

A. Wierinckx
  • Fonction : Auteur
M. Roche
  • Fonction : Auteur
J. Trouillas
  • Fonction : Auteur
G. Raverot
  • Fonction : Auteur
J. Lachuer
  • Fonction : Auteur

Résumé

Since the presence of microRNAs was first observed in normal pituitary, the majority of scientific publications addressing their role and the function of microRNAs in the pituitary have been based on pituitary tumor studies. In this review, we briefly describe the involvement of microRNAs in the synthesis of pituitary hormones and we present a comprehensive inventory of microRNA suppressors and inducers of pituitary tumors. Finally, we summarize the functional role of microRNAs in tumorigenesis, progression and aggressiveness of pituitary tumors, mechanisms contributing to the regulation (transcription factors, genomic modifications or epigenetic) or modulation (pharmacological treatment) of microRNAs in these tumors, and the interest of thoroughly studying the expression of miRNAs in body fluids.

Mots clés

Fichier non déposé

Dates et versions

hal-02487203 , version 1 (21-02-2020)

Identifiants

Citer

A. Wierinckx, M. Roche, Catherine Legras-Lachuer, J. Trouillas, G. Raverot, et al.. MicroRNAs in pituitary tumors. Molecular and Cellular Endocrinology, 2017, Small non-coding RNAs (and microRNAs) in endocrinology, 456 (C), pp.51-61. ⟨10.1016/j.mce.2017.01.021⟩. ⟨hal-02487203⟩
12 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More