WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2019

WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis

Yanfei Ma
  • Fonction : Auteur
Andrej Miotk
  • Fonction : Auteur
Olga Ermakova
  • Fonction : Auteur
Anna Medzihradszky
  • Fonction : Auteur
Christophe Gaillochet
  • Fonction : Auteur
Gözde Utan
  • Fonction : Auteur
Klaus Brackmann
  • Fonction : Auteur
Teva Vernoux
Jan Lohmann
  • Fonction : Auteur

Résumé

To maintain the balance between long-term stem cell self-renewal and differentiation, dynamic signals need to be translated into spatially precise and temporally stable gene expression states. In the apical plant stem cell system, local accumulation of the small, highly mobile phytohormone auxin triggers differentiation while at the same time, pluripotent stem cells are maintained throughout the entire life-cycle. We find that stem cells are resistant to auxin mediated differentiation, but require low levels of signaling for their maintenance. We demonstrate that the WUSCHEL transcription factor confers this behavior by rheostatically controlling the auxin signaling and response pathway. Finally, we show that WUSCHEL acts via regulation of histone acetylation at target loci, including those with functions in the auxin pathway. Our results reveal an important mechanism that allows cells to differentially translate a potent and highly dynamic developmental signal into stable cell behavior with high spatial precision and temporal robustness.

Domaines

Morphogenèse
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hal-02386567 , version 1 (25-05-2020)

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Yanfei Ma, Andrej Miotk, Olga Ermakova, Christian Wenzl, Anna Medzihradszky, et al.. WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis. Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-13074-9⟩. ⟨hal-02386567⟩
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