Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019) - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Particle & Particle Systems Characterization Année : 2019

Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019)

Xue Li
Patrick Couvreur
Christian Serre
Jiwen Zhang
Ruxandra Gref

Résumé

Back Cover : As demonstrated by Ruxendra Gref and co‐workers in article number 1800360, two synergic drugs, amoxicillin and potassium clavulanate, were co‐encapsulated within highly porous nanoparticles made of metal‐organic frameworks (nanoMOFs). Within the interconnected 3D structure, each drug located in a separate compartment and these findings were supported by molecular simulations. NanoMOFs were efficiently internalized in infected macrophages and contributed together with the entrapped drugs to kill intracellular bacteria.

Dates et versions

hal-02367416 , version 1 (17-11-2019)

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Xue Li, Nicolas Semiramoth, Shaun Hall, Virginie Tafani, Jérôme Josse, et al.. Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019). Particle & Particle Systems Characterization, 2019, 36 (3), pp.Back cover. ⟨10.1002/ppsc.201970009⟩. ⟨hal-02367416⟩
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