A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2019

A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

G. Humphrey
  • Fonction : Auteur
S. Bassirian
  • Fonction : Auteur
S. Singh
  • Fonction : Auteur
C. Faulkner
  • Fonction : Auteur
E. Rizo
  • Fonction : Auteur
L. Richards
  • Fonction : Auteur
Z. Z. Xu
  • Fonction : Auteur
M. R. Downes
  • Fonction : Auteur
R. M. Evans
  • Fonction : Auteur
C. B. Sirlin
  • Fonction : Auteur
R. Loomba
  • Fonction : Auteur

Résumé

The presence of cirrhosis in nonalcoholic-fatty-liver-disease (NAFLD) is the most important predictor of liver-related mortality. Limited data exist concerning the diagnostic accuracy of gut-microbiome-derived signatures for detecting NAFLD-cirrhosis. Here we report 16S gut-microbiome compositions of 203 uniquely well-characterized participants from a prospective twin and family cohort, including 98 probands encompassing the entire spectrum of NAFLD and 105 of their first-degree relatives, assessed by advanced magnetic-resonance-imaging. We show strong familial correlation of gut-microbiome profiles, driven by shared housing. We report a panel of 30 features, including 27 bacterial features with discriminatory ability to detect NAFLD-cirrhosis using a Random Forest classifier model. In a derivation cohort of probands, the model has a robust diagnostic accuracy (AUROC of 0.92) for detecting NAFLD-cirrhosis, confirmed in a validation cohort of relatives of proband with NAFLD-cirrhosis (AUROC of 0.87). This study provides evidence for a fecal-microbiome-derived signature to detect NAFLD-cirrhosis.

Dates et versions

hal-02195292 , version 1 (26-07-2019)

Identifiants

Citer

C. Caussy, A. Tripathi, G. Humphrey, S. Bassirian, S. Singh, et al.. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nature Communications, 2019, 10 (1), pp.1406. ⟨10.1038/s41467-019-09455-9⟩. ⟨hal-02195292⟩
18 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More