%0 Journal Article %T In vitro effects of isoprinosine and of a dipeptide methyl ester on Echinococcus multilocularis. %+ Institut des Sciences Pharmaceutiques et Biologiques (ISPB) %+ Molécules bioactives et chimie médicinale (B2MC) %+ Université Claude Bernard Lyon 1 (UCBL) %A Lawton, Philippe %A Walchshofer, Nadia %A Sarciron, Marie-Elisabeth %< avec comité de lecture %@ 0022-149X %J Journal of Helminthology %I Cambridge University Press (CUP) %V 75 %N 3 %P 251-257 %8 2001 %D 2001 %R 10.1079/JOH200049 %Z Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologyJournal articles %X A protoscoleces/vesicles in vitro maintenance test with assessment of viability by eosin exclusion was used to evaluate the quantitative and qualitative activities of isoprinosine, its active component inosine and the dipeptide methylester L-Phe-Phe-OMe on isolated protoscoleces of Echinococcus multilocularis for 24 and 48 h. Isoprinosine and inosine showed dose- and time-dependent activity, the latter displaying a more rapid effect than the former. A high activity was shown with L-Phe-Phe-OMe, when compared to praziquantel. Ultrastructural alterations were much more striking with L-Phe-Phe-OMe, with an effect similar to that of praziquantel, whereas the chemotherapeutic activity of inosine and isoprinosine appeared to be directed against a metabolic target, with a lethal effect not immediately visible at the ultrastructural level. Thus, the previously reported in vivo activities of these drugs result largely from a direct effect on the parasite. %G English %2 https://univ-lyon1.hal.science/hal-02110986/document %2 https://univ-lyon1.hal.science/hal-02110986/file/13-Lawton%2001%20modifi%C3%A9%20%281%29.pdf %L hal-02110986 %U https://univ-lyon1.hal.science/hal-02110986 %~ UNIV-LYON1 %~ B2MC %~ UDL %~ UNIV-LYON