MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Investigation Année : 2012

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

Résumé

Pregnancy and obesity are frequently associated with diminished insulin sensitivity, which is normally compensated for by an expansion of the functional β cell mass that prevents chronic hyperglycemia and development of diabetes mellitus. The molecular basis underlying compensatory β cell mass expansion is largely unknown. We found in rodents that β cell mass expansion during pregnancy and obesity is associated with changes in the expression of several islet microRNAs, including miR-338-3p. In isolated pancreatic islets, we recapitulated the decreased miR-338-3p level observed in gestation and obesity by activating the G protein-coupled estrogen receptor GPR30 and the glucagon-like peptide 1 (GLP1) receptor. Blockade of miR-338-3p in β cells using specific anti-miR molecules mimicked gene expression changes occurring during β cell mass expansion and resulted in increased proliferation and improved survival both in vitro and in vivo. These findings point to a major role for miR-338-3p in compensatory β cell mass expansion occurring under different insulin resistance states.

Dates et versions

hal-01982002 , version 1 (15-01-2019)

Identifiants

Citer

Cécile Jacovetti, Amar Abderrahmani, Géraldine Parnaud, Jean-Christophe Jonas, Marie-Line Peyot, et al.. MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity. Journal of Clinical Investigation, 2012, 122 (10), pp.3541-3551. ⟨10.1172/JCI64151⟩. ⟨hal-01982002⟩
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