Generation of helper and cytotoxic CD4+T cell clones specific for the minor histocompatibility antigen H-Y, after in vitro priming of human T cells by HLA-identical monocyte-derived dendritic cells. - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Transplantation Année : 2001

Generation of helper and cytotoxic CD4+T cell clones specific for the minor histocompatibility antigen H-Y, after in vitro priming of human T cells by HLA-identical monocyte-derived dendritic cells.

Résumé

There is now convincing evidence that minor histocompatibility antigens (mHag) may play a significant role in the pathogenesis of graft-versus-host disease after HLA-identical bone marrow transplantation. Indeed, in this clinical situation, T cells specific for mHag have been isolated. Here, we addressed whether one can generate mHag-specific T cells in vitro, without any in vivo immunization, among healthy blood donors.
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Dates et versions

hal-01981127 , version 1 (14-01-2019)

Identifiants

  • HAL Id : hal-01981127 , version 1
  • PUBMED : 11391234

Citer

A Eljaafari, A Farre, K Duperrier, J. Even, H. Vié, et al.. Generation of helper and cytotoxic CD4+T cell clones specific for the minor histocompatibility antigen H-Y, after in vitro priming of human T cells by HLA-identical monocyte-derived dendritic cells.. Transplantation, 2001, 71 (10), pp.1449-55. ⟨hal-01981127⟩
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