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Journal Articles Medicine Year : 2016

Recurrent Wheezing in Infants: A Population-Based Study

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Recurrent wheezing (RW) has a significant impact on infants, caregivers, and society, but morbidity and related medical resource utilization (MRU) have not been thoroughly explored. The burden of RW needs to be documented with population-based data. The objective was to assess the characteristics, medical management, and MRU of RW infants identified from national claims data.Infants aged from 6 to 24 months, receiving >=2 dispensations of respiratory drugs within 3 months, and presenting a marker of poor control (index date), were selected. During the 6 months after index date, MRU was described in the cohort and among 3 subgroups with more severe RW, defined as >=4 dispensations of respiratory drugs, >=3 dispensations of oral corticosteroids (OCS), or >=1 hospitalization for respiratory symptoms.A total of 115,489 infants had RW, corresponding to 8.2% of subjects in this age group. During follow-up, 68.7% of infants received inhaled corticosteroids, but only 1.8 U (unit) were dispensed over 6 months, suggesting discontinuous use. Control was mostly inadequate: 61.7% of subjects received OCS, 80.2% antibiotics, and 71.2% short-acting beta-agonists, and medical/paramedical visits were numerous, particularly for physiotherapy. Severe RW concerned 39.0% of the cohort; 32.8% and 11.7% of infants had repeated use of respiratory drugs and OCS, respectively, and 5.5% were hospitalized for respiratory symptoms.In this real-life nation-wide study, RW was common and infants had poor control and high MRU. Interventions are needed to support adequate use of controller therapy, and to improve medical care.

Dates and versions

hal-01838969 , version 1 (13-07-2018)



Manon Belhassen, Jacques de Blic, L. Laforest, Valérie Laigle, Céline Chanut-Vogel, et al.. Recurrent Wheezing in Infants: A Population-Based Study. Medicine, 2016, 95 (15), pp.e3404. ⟨10.1097/MD.0000000000003404⟩. ⟨hal-01838969⟩
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