Treatment patterns and comparative effectiveness in elderly acute myeloid leukemia patients (age 70 years or older): the Lyon-university hospital experience - Université Claude Bernard Lyon 1 Access content directly
Journal Articles Leukemia & lymphoma Year : 2017

Treatment patterns and comparative effectiveness in elderly acute myeloid leukemia patients (age 70 years or older): the Lyon-university hospital experience

Jeune C. Le
  • Function : Author
M. Elhamri
  • Function : Author
M. Balsat
  • Function : Author
I. Tigaud
  • Function : Author
A. Plesa
  • Function : Author
F. Barraco
  • Function : Author
H. Labussiere
  • Function : Author
S. Ducastelle
  • Function : Author
Gilles Salles
X. Thomas
  • Function : Author

Abstract

The treatment of very elderly patients (\textgreater/=70 years) with acute myeloid leukemia remains controversial. We present here 302 patients seen over a 14-year period in order to understand the real-world treatment patterns and outcomes in this patient population. Less than 25% of patients achieved a complete remission. The median overall survival was 12.4, 11.5 and 2.6 months, with a 3-year rates of 27%, 17% and 6%, for non-acute promyelocytic leukemia patients receiving intensive chemotherapy, lower-intensity therapy or best supportive care (BSC), respectively. In all ages, results were not significantly different among patients receiving low-intensity therapy and intensive chemotherapy, but significantly worse in those treated with BSC only. Similarly, intensive chemotherapy and low-intensity therapy gave better survival rates than BSC in patients with favorable- or intermediate-risk cytogenetics and in those with unfavorable cytogenetics (p \textless 0.0001 and p = 0.04, respectively)
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Dates and versions

hal-01795720 , version 1 (18-05-2018)

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M. Heiblig, Jeune C. Le, M. Elhamri, M. Balsat, I. Tigaud, et al.. Treatment patterns and comparative effectiveness in elderly acute myeloid leukemia patients (age 70 years or older): the Lyon-university hospital experience. Leukemia & lymphoma, 2017, 58, pp.110-117. ⟨10.1080/10428194.2016.1180688⟩. ⟨hal-01795720⟩
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