Synthesis, biological activity and molecular modelling of the 53-54 ketomethylene analogue of HEL(52-61) - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Protein and Peptide Letters Année : 1998

Synthesis, biological activity and molecular modelling of the 53-54 ketomethylene analogue of HEL(52-61)

Résumé

The synthesis of the 53-54 ketomethylene isostere of HEL(52-61), an antigenic decapeptide, was realised by convergent Fmoc solid-phase peptide synthesis. In addition to the target peptide, an unexpected hydroxysuccinyl by-product was recovered. The two ketomethylene epimers did not exhibit any stimulating or competitive activity. Molecular modelling studies of the analogues-MHC-II I-Ak complex suggested a departure from the canonical polyproline II conformation which could account for the absence of binding to I- Ak molecule
Fichier principal
Vignette du fichier
1998 - Prot Pept Letters 98 manuscrit.pdf (511.83 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01709968 , version 1 (15-02-2018)

Identifiants

  • HAL Id : hal-01709968 , version 1

Citer

Laurent Ettouati, Joseph Richard Casimir, Isabelle Raynaud, Marie-Claude Biémont-Trescol, Pierre-Alain Carrupt, et al.. Synthesis, biological activity and molecular modelling of the 53-54 ketomethylene analogue of HEL(52-61). Protein and Peptide Letters, 1998, 5 (4), pp.221-229. ⟨hal-01709968⟩
82 Consultations
21 Téléchargements

Partager

Gmail Facebook X LinkedIn More