68 Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Nanomedicine Année : 2017

68 Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy

Résumé

Aim: The aim of this study was to develop a dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging probe by radiolabeling gadolinium-containing AGuIX derivatives with the positron-emitter Gallium-68 (68Ga). Materials & methods: AGuIX@NODAGA nanoparticles were labeled with 68Ga at high efficiency. Tumor accumulation in an appropriate disease model was assessed by ex vivo biodistribution and in vivo PET/MR imaging. Results: 68Ga-AGuIX@NODAGA was proven to passively accumulate in U87MG human glioblastoma tumor xenografts. Metabolite assessment in serum, urine and tumor samples showed that 68Ga-AGuIX@NODAGA remains unmetabolized up to at least 60 min postinjection. Conclusion: This study demonstrates that 68Ga-AGuIX@NODAGA can be used as a dual-modality PET/MR imaging agent with passive accumulation in the diseased area, thus showing great potential for PET/MR image-guided radiation therapy.
Fichier principal
Vignette du fichier
nnm-2017-0032.pdf (2.92 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01689547 , version 1 (22-01-2018)

Identifiants

Citer

Penelope Bouziotis, Dimitris Stellas, Eloise Thomas, Charles Truillet, Charalampos Tsoukalas, et al.. 68 Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy. Nanomedicine, 2017, 12 (13), pp.1561 - 1574. ⟨10.2217/nnm-2017-0032⟩. ⟨hal-01689547⟩
164 Consultations
175 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More