ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Nucleic Acids Research Année : 2018

ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets

Delphine Dauga
Alexandra Louis
Maëlle Bellec
Lionel Christiaen
Hiroki Nishida
Yutaka Satou
  • Fonction : Auteur
  • PersonId : 995013
Michael Veeman

Résumé

ANISEED (www.aniseed.cnrs.fr) is the main model organism database for tunicates, the sister-group of vertebrates. This release gives access to annotated genomes, gene expression patterns, and anatomical descriptions for nine ascidian species. It provides increased integration with external molecular and taxonomy databases, better support for epigenomics datasets, in particular RNA-seq, ChIP-seq and SELEX-seq, and features novel interactive interfaces for existing and novel datatypes. In particular, the cross-species navigation and comparison is enhanced through a novel taxonomy section describing each represented species and through the implementation of interactive phylogenetic gene trees for 60% of tunicate genes. The gene expression section displays the results of RNA-seq experiments for the three major model species of solitary ascidians. Gene expression is controlled by the binding of transcription factors to cis-regulatory sequences. A high-resolution description of the DNA-binding specificity for 131 Ciona robusta (formerly C. intestinalis type A) transcription factors by SELEX-seq is provided and used to map candidate binding sites across the Ciona robusta and Phallusia mammillata genomes. Finally, use of a WashU Epigenome browser enhances genome navigation, while a Genomicus server was set up to explore microsynteny relationships within tunicates and with vertebrates, Amphioxus, echinoderms and hemichordates.
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Dates et versions

hal-01636650 , version 1 (18-12-2019)

Identifiants

Citer

Matija Brozovic, Christelle Dantec, Justine Dardaillon, Delphine Dauga, Emmanuel Faure, et al.. ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets. Nucleic Acids Research, 2018, 46 (D1), pp.D718-D725. ⟨10.1093/nar/gkx1108⟩. ⟨hal-01636650⟩
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