Degree of Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Angewandte Chemie International Edition Année : 2017

Degree of Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy

Résumé

Biomimetic spinning of artificial spider silk requires that the terminal domains of designed minispidroins undergo specific structural changes in concert with the β-sheet conversion of the repetitive region. Herein, we combine solution and solid-state NMR methods to probe domain-specific structural changes in the NT2RepCT minispidroin, which allows us to assess the degree of biomimicry of artificial silk spinning. In addition, we show that the structural effects of post-spinning procedures can be examined. By studying the impact of NT2RepCT fiber drying, we observed a reversible beta-to-alpha conversion. We think that this approach will be useful for guiding the optimization of artificial spider silk fibers.
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Dates et versions

hal-01587073 , version 1 (13-09-2017)

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Martins Otikovs, Marlene Andersson, Qiupin Jia, Kerstin Nordling, Qing Meng, et al.. Degree of Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy. Angewandte Chemie International Edition, 2017, 56 (41), pp.12571-12575. ⟨10.1002/anie.201706649⟩. ⟨hal-01587073⟩
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