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Article Dans Une Revue Bioelectrochemistry Année : 2008

Novel engineered ion channel provides controllable ion permeability for polyelectrolyte microcapsu

Résumé

The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of “smart” biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.

Dates et versions

hal-01179872 , version 1 (23-07-2015)

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Andrew R. Battle, Stella M. Valenzuela, Adam Mechler, Ryan J. Nichols, Slavica Praporski, et al.. Novel engineered ion channel provides controllable ion permeability for polyelectrolyte microcapsu. Bioelectrochemistry, 2008, pp.201-208. ⟨10.1002/adfm.200800483⟩. ⟨hal-01179872⟩
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