Multigram laboratory scale synthesis of α-Trifluoromethoxy Carbonyl Compounds. - Université Claude Bernard Lyon 1 Accéder directement au contenu
Article Dans Une Revue Organic Process Research and Development Année : 2014

Multigram laboratory scale synthesis of α-Trifluoromethoxy Carbonyl Compounds.

Résumé

α-trifluoromethoxy carbonyl compounds are valuable building blocks for the synthesis of various trifluoromethoxylated compounds. The best way to easily obtain them is the direct trifluoromethoxylation with the CF3O– anion, generated in situ from trifluoromethyl triflate. However, the necessary autogenous pressure generated during this reaction constitutes a main drawback for a multigram scale extrapolation. A specific procedure using adapted glassware has allowed a laboratory large-scale production (up to 50 g) of such building blocks with good yields.

Domaines

Chimie organique
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Dates et versions

hal-01154495 , version 1 (22-05-2015)

Identifiants

  • HAL Id : hal-01154495 , version 1

Citer

Barbion Julien, Pazenok Sergii, Vors Jean-Pierre, Langlois Bernard R., Billard Thierry. Multigram laboratory scale synthesis of α-Trifluoromethoxy Carbonyl Compounds.. Organic Process Research and Development, 2014, 18, pp.1037-1040. ⟨hal-01154495⟩
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