Due to various natural or anthropogenic hazards, buildings’ structural members can lose their bearing capacities which can lead to the building’s progressive collapse. The latter subject is of growing interest regarding the socio-economic context [1]. Academic research on progressive collapse took off in the early 2000s, with the 9/11 attacks on the Twin Towers (NY, 2001) [1]. Analyses on large structures are mainly done numerically. On the other side, most experiments are lead on smaller structural elements. Until now, these experiments have been limited by dimensions, dynamic forces and real-time control capabilities. In earthquake engineering, the pseudo-dynamic method (PsD) is often used [2]. Experimental tests are performed quasi-statically on a structural part, while the inertial forces are computed within a time integration scheme. An extension of the method is the sub-structured PsD trials, which consists of inserting the tested part in a larger finite element mesh. Sub-structuring enables accounting for the whole structure’s effect on the tested part [3]. The paper presents a first experimental campaign, which validated the interest of the approach on a simple structural part. Another experimental campaign is underway, on larger structural members to further comfort the method’s validity to study progressive collapse.