Pré-Publication, Document De Travail Année : 2023

Has AlphaFold3 achieved success for RNAs?

Résumé

Predicting the 3D structure of RNA is a significant chal- lenge despite ongoing advancements in the field. Although AlphaFold has successfully addressed this problem for proteins, RNA structure prediction raises difficulties due to fundamental differences between proteins and RNAs, which hinder direct adaptation. The latest release of AlphaFold, AlphaFold3, has broadened its scope to include multiple different molecules like DNA, ligands and RNA. While AlphaFold3 article discusses the results of the last CASP-RNA dataset, the scope of performances and the limitations for RNAs are unclear. In this article, we provide a comprehensive analysis of the performances of AlphaFold3 in the prediction of RNA 3D structures. Through an extensive benchmark over five different test sets, we discuss the performances and limitations of AlphaFold3. We also compare its per- formances with ten existing state-of-the-art ab initio, template-based and deep-learning approaches. Our results are freely available on the EvryRNA platform: https://evryrna.ibisc.univ-evry.fr/evryrna/alphafold3/.
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hal-04911522 , version 1 (24-01-2025)

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Clément Bernard, Guillaume Postic, Sahar Ghannay, Fariza Tahi. Has AlphaFold3 achieved success for RNAs?. 2025. ⟨hal-04911522⟩

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