Modelling cancer metabolism in vitro : current improvements and future challenges - CRCL-Ciblage des fonctions non-canoniques des protéines dans le cancer
Journal Articles FEBS Journal Year : 2022

Modelling cancer metabolism in vitro : current improvements and future challenges

Abstract

Advances in cancer biology over the past decades have revealed that metabolic adaptation of cancer cells is an essential aspect of tumorigenesis. However, recent insights into tumour metabolism in vivo have revealed dissimilarities with results obtained in vitro. This is partly due to the reductionism of in vitro cancer models that struggle to reproduce the complexity of tumour tissues. This review describes some of the discrepancies in cancer cell metabolism between in vitro and in vivo conditions, and presents current methodological approaches and tools used to bridge the gap with the clinically relevant microenvironment. As such, these approaches should generate new knowledge that could be more effectively translated into therapeutic opportunities.
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Dates and versions

hal-04132220 , version 1 (28-06-2023)

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Helena Dragic, Cedric Chaveroux, Erika Cosset, Serge N Manie. Modelling cancer metabolism in vitro : current improvements and future challenges. FEBS Journal, 2022, ⟨10.1111/febs.16704⟩. ⟨hal-04132220⟩
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