Article Dans Une Revue Current Diabetes Reports Année : 2021

Immunological Monitoring in Beta Cell Replacement: Towards a Pathophysiology-Guided Implementation of Biomarkers

Résumé

Purpose of review : Graft biopsy, which is invasive and impossible in case of islet transplantation. This review synthetizes the current pathophysiological knowledges and discuss the interest of available immune biomarkers. Recent findings: Despite the central role of auto-(recurrence of T1D) and allo-(T-cell mediated rejection) immune cellular responses, the latter are not directly monitored in routine. In striking contrast, there have been undisputable progresses in monitoring of auto and alloantibodies. Summary: Except for pancreas recipients in whom anti-donor HLA antibodies can be directly responsible for antibody-mediated rejection, autoantibodies (and alloantibodies in islet recipients) have no direct pathogenic effect. However, their fluctuation offers a surrogate marker for the activation status of T cells (because antibody generation depends on T cells). This illustrates the necessity to understand the pathophysiology when interpreting a biomarker and selecting the appropriate treatment.
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hal-04955935 , version 1 (19-02-2025)

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Fanny Buron, Sophie Reffet, Lionel Badet, Emmanuel Morelon, Olivier Thaunat. Immunological Monitoring in Beta Cell Replacement: Towards a Pathophysiology-Guided Implementation of Biomarkers. Current Diabetes Reports, 2021, 21 (6), pp.19. ⟨10.1007/s11892-021-01386-4⟩. ⟨hal-04955935⟩
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