Article Dans Une Revue Journal of the European Academy of Dermatology and Venereology Année : 2022

Unmet clinical needs and burden of disease in hidradenitis suppurativa: real‐world experience from EU5 and US

J R Ingram
  • Fonction : Auteur
  • PersonId : 1509042
V Bettoli
J I Espy
  • Fonction : Auteur
G Kokolakis
A Martorell
H Wallinger
  • Fonction : Auteur
E Coak
  • Fonction : Auteur
T Kasparek
  • Fonction : Auteur
E Muscianisi
  • Fonction : Auteur
C Richardson
  • Fonction : Auteur
A B Kimball

Résumé

Background Hidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating skin disease characterized by painful deep lesions and associated with substantial disease burden.

Objectives The objective of this study was to describe physician-and patient-reported clinical unmet needs from a real-world perspective.

Methods This study used data from the Adelphi HS Disease Specific Programme, a point-in-time survey of dermatologists and their patients with HS in Europe and the United States. Dermatologists completed patient record forms (PRFs) for 5-7 consecutively consulting patients with HS; patients or carers of patients also optionally completed a patient/carer self-completion questionnaire (PSC/CSC). Data collection included demographics, symptomatology and impact on quality of life (QoL).

Results Dermatologists (N = 312) completed PRFs for 1787 patients with HS; patient-and carer-reported questionnaires (PSC/CSC) were completed for 33.1% (591/1787) of patients. The mean age was 34.4 AE 12.2 years and 57.6% of patients were female (1029/1787). Physician-judged disease severity at sampling was categorized as mild in 66.0% (1179/1787), moderate in 29.3% (523/1787) and severe in 4.7% (85/1787) of patients. Deterioration or unstable condition over the previous 12 months was described by 17.1% [235/1372] and 12.6% [41/325] of physician-and patient/carerreported cases, respectively. Despite receiving treatment, high proportions of patients still experienced symptoms at sampling (general pain/discomfort [49.5%, 885/1787]; inflammation/redness of lesions/abscesses [46.1%, 823/1787] and itching [29.9%, 535/1787]); these symptoms were more frequent in patients with moderate or severe disease.

Fichier principal
Vignette du fichier
JDV-36-1597.pdf (546) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
licence

Dates et versions

hal-04953268 , version 1 (18-02-2025)

Licence

Identifiants

Citer

J R Ingram, V Bettoli, J I Espy, G Kokolakis, A Martorell, et al.. Unmet clinical needs and burden of disease in hidradenitis suppurativa: real‐world experience from EU5 and US. Journal of the European Academy of Dermatology and Venereology, 2022, 36, pp.1597 - 1605. ⟨10.1111/jdv.18163⟩. ⟨hal-04953268⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

More